摘要 |
Production of 3-hydroxymethyl-quinuclidine (I) comprises either (A) converting 3,3-methyleneoxy-quinuclidine (II) or 3-quinuclidinone (IV) to 3-methoxymethyl-3-quinuclidinol (IV), converting (IV) to 3-formyl-quinuclidine (V), and reducing (V) to (I), or (B) converting (IV) to 3-cyano-quinuclidine (VI), hydrolyzing (VI) to quinuclidine-3-carboxylic acid (VII) and reducing (VII) to (I). Production of 3-hydroxymethyl-quinuclidine of formula (I) comprises either: (A) converting 3,3-methyleneoxy-quinuclidine of formula (II) or 3-quinuclidinone of formula (IV) to 3-methoxymethyl-3-quinuclidinol of formula (IV), converting (IV) to 3-formyl-quinuclidine of formula (V), and reducing (V) to (I); or (B) converting (III) to 3-cyano-quinuclidine of formula (VI), hydrolyzing (VI) to quinuclidine-3-carboxylic acid of formula (VII) and reducing (VII) to (I): An Independent claim is also included for 3-methoxymethyl-3-quinuclidinol of formula (IV).
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