发明名称 |
METHOD FOR SEARCHING PHYSIOLOGICALLY ACTIVE SUBSTANCES, PROCESS FOR PRODUCING THESES SUBSTANCES AND DRUGS FOUND BY THE SEARCHING METHOD |
摘要 |
A method for effeciently searching novel physiologically active substances under a certain predictability. This searching method comprises, among receptors of cells producing an antagonist to a substance in vivo or receptors of cells producing an antagonist to the cells per se, finding a receptor having amino acid sequences of two or more sizes by comparing the cDNA sequences of the receptor; and then examining which region in the longer receptor is missed in the shorter receptor by comparing the above cDNA sequences. By using this method, remedies for diabetes comprising a peptide having the amino acid sequence represented by SEQ ID NO:1 or 5, insulin production regulators comprising a peptide having the amino acid sequence represented by SEQ ID NO:2, and gastric secretion inhibitors comprising a peptide having the amino acid sequence represented by SEQ ID NO:3 or 4 are provided.
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申请公布号 |
WO9951627(A1) |
申请公布日期 |
1999.10.14 |
申请号 |
WO1999JP01796 |
申请日期 |
1999.04.05 |
申请人 |
NAKOSHI, HIDEO;SAKAMOTO, KENJI |
发明人 |
SAKAMOTO, KENJI |
分类号 |
A61K38/00;C07K7/06;C07K7/08;(IPC1-7):C07K7/06;A61K38/26;A61K38/30 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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