PYRROLO[1,2-a]PYRAZINE sPLA2 INHIBITOR

摘要

Formula (I), wherein R<1> is -(L<1>)-R<6> wherein L<1> is a divalent linking group of 1 to 18 atoms or the like, and R<6> is a carbocyclic ring substituted by at least one non-interfering substituent or the like; R<2> is C1 to C3 alkyl, C3 to C4 cycloalkyl or the like group; R<3> is -(L<2>)-(acidic group); R<4> and R<5> are hydrogen atoms, non-interfering substituents, carbocyclic groups or the like; R<A> is -C(=X)-C(=X)-NH2 or the like; and X is independently oxygen atom or sulfur atom; the prodrugs thereof, their pharmaceutically acceptable salts, or their solvates, and a composition for inhibiting sPLA2 containing them as effective ingredients.