发明名称 AMINOALKYL SUBSTITUTED 5,6,7,8-TETRAHYDRO-9H PYRIMIDINO[2,3-B]INDOLE AND 5,6,7,8-TETRAHYDRO-9H-PYRIMIDINO[4,5-B]INDOLE DERIVATIVES: CRF1 SPECIFIC LIGANDS
摘要 Disclosed are compounds of formula (I), wherein Ar, R1, W, X and m are substituents as defined herein. These compounds are modulators of CRF receptors and are therefore useful for treating affective disorder, anxiety, depression, headache, irritable bowel syndrome, post-traumatic stress disorder, supranuclear palsy, immune suppression, Alzheimer's disease, gastrointestinal diseases, anorexia nervosa or other feeding disorder, drug addiction, drug or alcohol withdrawal symptoms, inflammatory diseases, cardiovascular or heart-related diseases, fertility problems, human immunodeficiency virus infections, hemorrhagic stress, obesity, infertility, head and spinal cord traumas, epilepsy, stroke, ulcers, amyotrophic lateral sclerosis, hypoglycemia or a disorder the treatment of which can be effected or facilitated by antagonizing CRF, including but not limited to disorders induced or facilitated by CRF, in mammals, comprising: administering to the mammal a therapeutically effective amount of a compound of Formula (I).
申请公布号 CA2326319(A1) 申请公布日期 1999.10.14
申请号 CA19992326319 申请日期 1999.04.01
申请人 NEUROGEN CORPORATION 发明人 HORVATH, RAYMOND F.;DARROW, JAMES W.;MAYNARD, GEORGE D.
分类号 A61K31/437;A61K31/519;A61P1/00;A61P1/04;A61P1/14;A61P3/04;A61P3/08;A61P9/00;A61P15/00;A61P25/00;A61P25/06;A61P25/08;A61P25/22;A61P25/24;A61P25/28;A61P25/30;A61P29/00;A61P31/12;A61P37/06;C07D471/04;C07D487/04;(IPC1-7):C07D471/04;C07D207/00;C07D213/00;A61K31/40;A61K31/44 主分类号 A61K31/437
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