发明名称 |
AMINOALKYL SUBSTITUTED 5,6,7,8-TETRAHYDRO-9H PYRIMIDINO[2,3-B]INDOLE AND 5,6,7,8-TETRAHYDRO-9H-PYRIMIDINO[4,5-B]INDOLE DERIVATIVES: CRF1 SPECIFIC LIGANDS |
摘要 |
Disclosed are compounds of formula (I), wherein Ar, R1, W, X and m are substituents as defined herein. These compounds are modulators of CRF receptors and are therefore useful for treating affective disorder, anxiety, depression, headache, irritable bowel syndrome, post-traumatic stress disorder, supranuclear palsy, immune suppression, Alzheimer's disease, gastrointestinal diseases, anorexia nervosa or other feeding disorder, drug addiction, drug or alcohol withdrawal symptoms, inflammatory diseases, cardiovascular or heart-related diseases, fertility problems, human immunodeficiency virus infections, hemorrhagic stress, obesity, infertility, head and spinal cord traumas, epilepsy, stroke, ulcers, amyotrophic lateral sclerosis, hypoglycemia or a disorder the treatment of which can be effected or facilitated by antagonizing CRF, including but not limited to disorders induced or facilitated by CRF, in mammals, comprising: administering to the mammal a therapeutically effective amount of a compound of Formula (I).
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