TIN-FREE RHENIUM(V) COMPLEXES AND METHODS FOR THEIR PREPARATION

摘要

There are provided methods for the treatment or diagnosis of cancer in a mammal, including the step of administering to the mammal an effective amount of a substantially tin-free solution of <188>Re(V)-2,3-dimercaptosuccinic acid, <186>Re(V)-2,3-dimercaptosuccinic acid or mixtures thereof. There is further provided a process for the preparation of substantially tin-free Re(V)-2,3-dimercaptosuccinic acid, including the step of reducing a solution of a rhenium(VII) species in the presence of at least a 10<5>-fold molar excess of 2,3-dimercaptosuccinic acid with at least a 10<5>-fold molar excess of a sulfur dioxide releasing reducing agent at a pH of not greater than 6, wherein the molar excesses are based on the number of moles of the rhenium(VII) species in the solution.