QUINOLONECARBOXYLIC ACID DERIVATIVES OR SALTS THEREOF

摘要

Novel quinolonecarboxylic acid derivatives represented by general formula (1 ) which have potent antibacterial effects on gram-positive bacteria, in particular, Propionibacterium acnes, wherein R1 represents hydrogen or a carboxyl-protective group; R2 represents optionally substituted cycloalkyl; R3 represents hydrogen, halogeno, optionally substituted alkyl, alkoxy or alkylthio, optionally protected hydroxy or amino, or nitro; R4 represents optionally substituted alkyl or alkoxy; Z represents halogeno, optionally substituted alkyl, alkenyl, cycloalkyl, alkoxy, alkylthio, amino or pyridin- 4- yl or pyridin-3-yl optionally having one or more substituents selected from among optionally substituted hydroxy and amino.