发明名称 |
Pictet-spengler reaction for the synthesis of tetrahydroisoquinolines and related heterocyclic compounds |
摘要 |
A commercial scale process for the production of tetrahydroisoquinolines and related heterocyclics by reaction, in mildly acidic conditions, of aryl N-sulfonylethylamines in the presence of suitable Lewis acid, and a compound capable of in situ generation of formaldehyde. The process is further characterized by formaldehyde being generated by the reaction of the Lewis acid upon the formaldehyde generating agent, instead of being present as an initial reactant. The process further avoids the presence of initial water which destroys the Lewis acid before it can act upon the formaldehyde generating agent. |
申请公布号 |
AU711358(B2) |
申请公布日期 |
1999.10.14 |
申请号 |
AU19970039063 |
申请日期 |
1997.08.04 |
申请人 |
HOECHST MARION ROUSSEL, INC. |
发明人 |
TIMOTHY JAMES-NORMAN WATSON |
分类号 |
C07D217/02;C07D217/00;C07D217/06;C07D217/20;C07D221/20;(IPC1-7):C07D217/06 |
主分类号 |
C07D217/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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