发明名称 |
PRODRUGS OF PHOSPHOROUS-CONTAINING PHARMACEUTICALS |
摘要 |
Pharmaceutical compounds with the formula: Drug-P(=O)-O-Linker(-R2')k-R2 where Drug-P(=O)-O- is the residue of a drug comprising a phosphonate, phosphinate or phosphoryl function, such as alendronate or foscarnet, R2 and R2' (if present) are independently the acyl residue of an aliphatic amino acid; Linker is an at least difunctional moiety comprising a first function ester-bonded to the phosphonate, phosphinate or phosphoryl function spaced from a second function ester-bonded to R2; and k is 1 or zero; have enhanced bioavailability or other pharmacokinetic performance relative to the parent drug. |
申请公布号 |
CA2325523(A1) |
申请公布日期 |
1999.10.14 |
申请号 |
CA19992325523 |
申请日期 |
1999.03.30 |
申请人 |
MEDIVIR AB |
发明人 |
WAHLING, HORST;LINDSTROM, STEFAN;SUND, CHRISTIAN;WALLBERG, HANS;SALVADOR, LOURDES;ZHOU, XIAO-XIONG;JOHANSSON, NILS GUNNAR |
分类号 |
A61K31/662;A61K31/675;A61P3/14;A61P19/02;A61P19/08;A61P19/10;A61P29/00;A61P37/02;C07D;C07D473/32;C07F9/38;C07F9/40;C07F9/58;C07H19/06;C07H19/16 |
主分类号 |
A61K31/662 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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