MEASLES VIRUS MUTANT ANTIGEN AND GENE ENCODING THE SAME

摘要

Mutant measles virus antigens containing at least one protein antigen selected from the group consisting of (I) mutant measles virus H protein antigens and (II) mutant measles virus F protein antigens as specified below: (I) at least one measles virus H protein selected from the group consisting of a full-length protein of an amino acid sequence consisting of 617 amino acids in total described in SEQ ID NO.2 or 10 and specified peptide fragments thereof, and (II) at least one measles virus F protein antigen selected from the group consisting of a full-length protein of an amino acid sequence consisting of 550 amino acids in total described in SEQ ID NO:18 or 20 specified peptide fragment thereof; and mutant measles virus genes containing genes encoding the above measles virus antigens. The use of these antigens or genes encoding the same makes it possible to efficiently and economically provide attenuated live measles vaccines or gene vaccines suitable for epidemic measles virus stains and diagnostics for appropriately detecting the infection with epidemic measles virus stains.