发明名称 |
SUBSTITUTED BENZOYLGUANIDINES, PROCESS FOR THEIR PREPARATION, THEIR USE AS MEDICAMENT, AS INHIBITOR OF THE CELLULAR NA+/H+ EXCHANGE OR AS DIAGNOSTIC AGENT AND MEDICAMENT CONTAINING THEM. |
摘要 |
<p>There are described benzoylguanidines of the formula I <IMAGE> where R(1) to R(3) are H, Hal, (cyclo)alkyl, N3, CN, or OH, alkyloxy, phenyl, phenoxy or benzoyl, and their pharmacologically acceptable salts, but with the exception of the compounds benzoylguanidine, 4-chlorobenzoylguanidine, 3,4-dichlorobenzoylguanidine and 3- or 4-methylbenzoylguanidine. They are obtained by reaction of a compound II <IMAGE> where L is a leaving group, with guanidine.t</p> |
申请公布号 |
GR3024855(T3) |
申请公布日期 |
1998.01.30 |
申请号 |
GR19970402499T |
申请日期 |
1997.09.24 |
申请人 |
HOECHST AKTIENGESELLSCHAFT |
发明人 |
LANG, HANS-JOCHEN, DR.;WEICHERT, ANDREAS, DR.;KLEEMANN, HEINZ-WERNER, DR.;SCHWARK, JAN-ROBERT, DR.;SCHOLZ, WOLFGANG, DR.;ALBUS, UDO, DR. |
分类号 |
A61K31/165;A61K31/155;A61K31/166;A61K31/44;A61K31/47;A61K31/472;A61P1/04;A61P1/16;A61P3/10;A61P7/02;A61P9/00;A61P9/02;A61P9/06;A61P9/08;A61P9/10;A61P9/12;A61P11/00;A61P13/08;A61P13/12;A61P35/00;A61P43/00;C07C233/65;C07C277/08;C07C279/18;C07C279/22;C07D213/30;C07D213/56;C07D215/14;C07D215/50;C07D217/18;C07D217/24;(IPC1-7):C07C279/22 |
主分类号 |
A61K31/165 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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