NEURAMINIC ACID DERIVATIVE

摘要

PROBLEM TO BE SOLVED: To obtain a new compound having an excellent inhibiting activity for a sialidase and effective in treating influenza. SOLUTION: This compound is represented by formula I (R<1> is a 1-4C alkyl or the like; R<2> and R<3> are each H or a 2-25C aliphatic acyl; X is OH or the like; Y is NH2 or the like; Z is O or the like, except a compound, etc., in which R<1> is a 1-4C alkyl; R<2> and R<3> are each H or a 2-25C aliphatic acyl; X is a halogen or a 1-4C alkoxy; Y is NH2 and Z is O), e.g. 5-acetamido-4-(C-aminooxy- C-iminomethylammno)-7-O-hexanoyl-2,3,4,5-tetradeoxy-D-glycero-D-galact o-non-2- enopyranosic acid. The compound represented by formula I is obtained by a method, etc., for reacting a compound represented by formula II (R<2a> and R<3a> are each R<2> , R<3> or the like; X is X or the like; W is H or the like) with N,N'-di-t-butoxycarbonylthiourea, removing the protecting group of the resultant compound represented by formula III (Boa is t-butoxycarbonyl) and affording a compound represented by formula IV (W is H or the like).