发明名称 |
Inhibition of the binding of human IgE to its receptor by tetracyclic compounds for the alleviation of IgE-mediated immune response |
摘要 |
Disclosed are chemical agents with unexpected activity to inhibit the interactions between human immunoglobulin E (IgE) and its receptor (Fc epsilon RI) which interactions are known to be involved in triggering allergic responses. The agents may be used to module the allergic response in the treatment of various clinical conditions, including rhinitis, asthma, urticaria, atopic dermatitis, and anaphylacric shock. The agents can be formulated for oral, topical or parenteral administration.
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申请公布号 |
US5965605(A) |
申请公布日期 |
1999.10.12 |
申请号 |
US19970999348 |
申请日期 |
1997.12.29 |
申请人 |
HESKA CORPORATION |
发明人 |
CHENG, Y.-S. EDMOND;LIU, YUAN;CHU, JOHN;KINET, JEAN-PIERRE;JOUVIN, MARIE-HELENE;SUDO, YUKIO;QIAN, XIUQI |
分类号 |
A61K31/352;A61K31/4433;C07D311/82;(IPC1-7):A61K31/35 |
主分类号 |
A61K31/352 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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