发明名称 |
In vivo binding pair pretargeting |
摘要 |
A method for in-vivo targeting a functional moiety in a patient by administering a targeting moiety coupled to an affinity component, wherein the targeting moiety has affinity for binding sites in a target area, and administering a binding partner to the affinity component coupled to a functional moiety to localize the functional moiety in the target area. Preferably the targeting moiety is an antibody and the functional moiety is a radiometal when performing in vivo imaging or therapy. The affinity component may be a novel methotrexate analog. Preferably, the affinity component is thermo-stabilized.
|
申请公布号 |
US5965106(A) |
申请公布日期 |
1999.10.12 |
申请号 |
US19950461267 |
申请日期 |
1995.06.05 |
申请人 |
PERIMMUNE HOLDINGS, INC. |
发明人 |
POMATO, NICHOLAS;MCCABE, RICHARD P.;HAWKINS, GREGORY A.;BREDEHORST, REINHARD;KIM, CHONG-HO;VOGEL, CARL-WILHELM |
分类号 |
A61K47/48;A61K51/10;(IPC1-7):A61K39/395;A61K51/00 |
主分类号 |
A61K47/48 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|