Transgenic non-human mammal comprising a rabbit WAP promoter

摘要

PCT No. PCT/FR92/00533 Sec. 371 Date Feb. 10, 1994 Sec. 102(e) Date Feb. 10, 1994 PCT Filed Jun. 12, 1992 PCT Pub. No. WO92/22644 PCT Pub. Date Dec. 23, 1992A transgenic non-human mammal is provided where the genome of the mammal comprises a DNA construct comprising in operable association a rabbit WAP promoter and a DNA sequence encoding a heterologous protein. Methods of using the mammal in the production of recoverable amounts of a heterologous protein in the mammal's milk are discussed and described such that the mammal is a bio-reactor for a heterologous protein of interest. Furthermore, cells isolated from the mammal are provided for the production of a heterologous protein of interest in vitro, as well as, DNA constructs of the rabbit WAP promoter for the production of the transgenic non-human mammal.