| 摘要 |
The present invention provides methods and compositions for screening, diagnosis and prognosis of RA, for monitoring the effectiveness of RA treatment, and for drug development. RA-Diagnostic Features (RADFs), detectable by two-dimensional electrophoresis of serum or plasma are described. The invention further provides RA-Diagnostic Protein Isoforms (RPIs) detectable in synovial fluid, serum or plasma, preparations comprising isolated RPIs, antibodies immunospecific for RPIs, and kits comprising the aforesaid. |
