Gene therapy vector with osteocalcin promoter and genes for bone morphogenic proteins or growth factors

摘要

The present invention relates to novel compositions containing nucleotide sequences which can be used as therapeutic agents for curing a wide variety of bone and spinal disorders. More specifically, the present invention relates to novel viral vectors which are used to deliver bone growth factor genes which induce endochondral bone formation to numerous tissues. The expression of the bone growth factor genes is regulated by tissue specific and/or inducible promoters. The present invention further relates to novel methods for using the therapeutic compositions. Specifically, the methods of the invention involve administering a bone growth factor gene, either directly or systemically, to a site where bone repair and/or regeneration is necessary.