发明名称 |
Use of dipeptidyl peptidase (dpp4) for suppressing the malignant phenotype of cancer cells |
摘要 |
This invention provides a method of suppressing the malignant phenotype or inducing apoptosis of cancer cells in a subject, comprising introducing into the cancer cell an amount of a nucleic acid encoding a dipeptidyl peptidase IV protein or fibroblast activating protein- alpha , thereby suppressing the malignant phenotype of the cancer. This invention provides a method of treating a subject with cancer which comprises administering to the subject a pharmaceutical composition comprising a therapeutically effective amount of a purified dipeptidyl peptidase IV protein or fibroblast activating protein- alpha and a pharmaceutical acceptable carrier or diluent. This invention provides a method of inducing expression of dipeptidyl peptidase IV or fibroblast activating protein- alpha in cancer cells of a subject, comprising administering to the subject a pharmaceutical composition comprising a therapeutically effective amount of an agent capable of activating transcription of the dipeptidyl peptidase IV gene or fibroblast activating protein- alpha and a pharmaceutical acceptable carrier or diluent. |
申请公布号 |
AU3357299(A) |
申请公布日期 |
1999.10.11 |
申请号 |
AU19990033572 |
申请日期 |
1999.03.19 |
申请人 |
SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH |
发明人 |
ALAN N. HOUGHTON;UMADEVI V. WESLEY;JEDD D. WOLCHOK |
分类号 |
A61K38/19;A61K38/20;A61K38/21;A61K38/48;A61K48/00;A61P35/00 |
主分类号 |
A61K38/19 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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