| 摘要 |
The invention relates to nanoparticles with a biocompatible, biodegradable polyelectrolyte complex consisting of polycations and polyanions, and at least one bioactive agent. The nanoparticles are obtained by additionally treating the polyelectrolyte complex with at least one cross-linking agent after it has been formed. The invention also relates to a method for producing said nanoparticles. An active agent in combined or non-combined form and an aqueous solution of an acidic polymer substance and a basic polymer substance are brought together and the polyelectrolyte is then produced in a nanoparticulate form or optionally, is converted into a nanoparticulate form. The invention is characterised in that the nanoparticulate polyelectrolyte complex is then treated with at least one cross-linking agent. The inventive nanoparticles can be used for applying bioactive agents. They have the advantages of being very stable, enabling the controlled release of active agents and not producing the burst effect. Due to the method by which they are produced, the inventive nanoparticles also only have very few residues of organic solvents. |
