发明名称 |
Mutations in mitotic check point genes and methods of diagnosis |
摘要 |
The present invention is based on the understanding of the molecular basis of MIN in human tumours as related to a similar MIN phenotype in S. cerevisiae cells harboring mutations of yeast MMR genes. Following this paradigm, the present inventors identified the basis for CIN in human tumour cells as related to mitotic checkpoint defects. |
申请公布号 |
AU3187399(A) |
申请公布日期 |
1999.10.11 |
申请号 |
AU19990031873 |
申请日期 |
1999.03.16 |
申请人 |
THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE |
发明人 |
BERT VOGELSTEIN;KENNETH W. KINZLER;DAN CAHILL;CHRISTOPH LENGAVER |
分类号 |
A61K48/00;C07K14/47;C12Q1/68 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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