METHODS OF ASSAY OF COLLAGEN DESTRUCTION IN VIVO AND SETS FOR REALIZATION OF METHODS, HYBRIDOMA, MONOCLONAL ANTIBODY AND ITS FRAGMENT, PEPTIDES OF COLLAGEN AND METHOD OF ASSAY

摘要

FIELD: biotechnology, biochemistry, medicine. SUBSTANCE: assay and recording of collagen destruction are carried out by contact of immunologically binding components to cross-linked telopeptides formed from collagen type I, II, III that contains opened or unopened pyridinium ring of 3-hydroxypyridinium cross-link with the biological fluid. Cross-link is hydroxylysylpyridinoline or lysylpyridinoline. Invention can be used for assay of collagen destruction in vivo. EFFECT: diagnosis of diseases associated with collagen destruction. 29 cl, 14 dwg, 3 ex