Keto acid salts and amine derivatives, and their use for preparing medicines

摘要

The invention concerns the use of compounds of general formula (I): (X)n1,Y,(Z)n2 wherein n1 and n2 represent 0 or 1; X represents a natural amino acid, in particular an amino acid selected among ornithine, arginine, lysine, histidine or glutamine; Y represents a keto acid of formula (II): R-CO-COOH wherein R represents -CH3, -CH2-CH3, -CH(CH3)2, -CH(CH3)-CH2-CH3, -CH2-CH(CH3)2, -CH2)2-COOH, -CH2)3-COOH; Z represents: a natural amino acid selected in particular among ornithine, arginine, lysine, histidine or glutamine; or a polyamine selected in particular among cadaverine, putrescine, spermidine, spermine or agmatine. Said compounds are useful for preparing a medicine for treating human or animal pathologies wherein are involved silent neurons, such as pathologies of the digestive tract, the bladder and the biliary ducts.