发明名称 |
MONOCLONAL ANTIBODIES, METHOD OF THEIR PREPARATION, USE OF THESE ANTIBODIES, AND PHARMACEUTICAL COMPOSITION THEM CONTAINING |
摘要 |
<p>The invention provides a monoclonal antibody that recognises a structurally continuous and extracellularly located epitope of human glycoprotein P (Pgp) which consists of a specific continuous epitope-forming amino acid sequence which is preferably located on the fourth extracellular loop of human Pgp and especially contained within the peptide of SEQUENCE ID NO. 1. Preferred antibodies according to the invention bind human Pgp specifically and with high avidity and thus may be used to identify human MDR cells when present as only a very low proportion of a cell population or when expressing human Pgp at only very low levels. The monoclonal antibody may be a whole antibody or antigen binding fragment thereof and may be prepared by hybridoma or recombinant DNA techniques.</p> |
申请公布号 |
SK280272(B6) |
申请公布日期 |
1999.10.08 |
申请号 |
SK19940001554 |
申请日期 |
1993.06.16 |
申请人 |
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发明人 |
CIANFRIGLIA MAURIZIO |
分类号 |
G01N33/53;A61K38/00;A61K39/395;A61P35/00;C07K14/705;C07K16/28;C07K16/30;C12N5/20;C12N15/09;C12P21/08;G01N33/574;G01N33/577;(IPC1-7):C12P21/08 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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