Method of identifying, diagnosing and treating synuclein positive neurodegenerative disorders

摘要

Methods of detecting synucleins to identify and diagnose synucleinopathies are provided. In addition, methods of treating such neurodegenerative disorders via modulation of production of selected synucleins and/or the formation of filamentous intracytoplasmic neuronal and glial inclusions from selected synucleins are described. A monoclonal antibody raised against Lewy bodies and specific for human alpha -synuclein is also provided.