发明名称 |
Process for producing cis-3-hydroxy-L-proline |
摘要 |
An industrially applicable process for producing cis-3-hydroxy-L-proline, which is useful as a raw material for medicines or as an additive to foods. In the process, L-proline is converted into cis-3-hydroxy-L-proline in the presence of an enzyme source which is derived from a microorganism belonging to the genus Streptomyces or Bacillus and which catalyzes hydroxylation of L-proline into cis-3-hydroxy-L-proline, a divalent iron ion and 2-ketoglutaric acid, in an aqueous medium, and the produced cis-3-hydroxy-L-proline is collected from the aqueous medium. A novel enzyme L-proline-3-hydroxylase, a gene of L-proline-3-hydroxylase which is useful for the process, a transformant containing the gene, and a process for producing L-proline-3-hydroxylase using the transformant.
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申请公布号 |
US5962292(A) |
申请公布日期 |
1999.10.05 |
申请号 |
US19960708856 |
申请日期 |
1996.09.09 |
申请人 |
KYOWA HAKKO KOGYO CO., LTD. |
发明人 |
OZAKI, AKIO;MORI, HIDEO;SHIBASAKI, TAKESHI;ANDO, KATSUHIKO;OCHIAI, KEIKO;CHIBA, SHIGERU;UOSAKI, YOICHI |
分类号 |
C12N9/02;C12P13/24;(IPC1-7):C12N9/02;C12N1/20;C12N15/00;C07H21/04 |
主分类号 |
C12N9/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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