发明名称 |
Calcium receptor-active molecules |
摘要 |
The present invention relates to the different roles inorganic ion receptors have in cellular and body processes. The present invention features: (1) molecules which can modulate one or more inorganic ion receptor activities, preferably the molecule can mimic or block an effect of an extracellular ion on a cell having an inorganic ion receptor, more preferably the extracellular ion is Ca2+ and the effect is on a cell having a calcium receptor; (2) inorganic ion receptor proteins and fragments thereof, preferably calcium receptor proteins and fragments thereof; (3) nucleic acids encoding inorganic ion receptor proteins and fragments thereof, preferably calcium receptor proteins and fragments thereof; (4) antibodies and fragments thereof, targeted to inorganic ion receptor proteins, preferably calcium receptor protein; and (5) uses of such molecules, proteins, nucleic acids and antibodies.
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申请公布号 |
US5962314(A) |
申请公布日期 |
1999.10.05 |
申请号 |
US19970943986 |
申请日期 |
1997.10.03 |
申请人 |
NPS PHARMACEUTICALS, INC.;BRIGHAM AND WOMEN'S HOSPITAL |
发明人 |
BROWN, EDWARD M.;HEBERT, STEVEN C.;GARRETT, JR., JAMES E. |
分类号 |
A61K31/135;A61K31/137;A61K31/165;A61K31/195;A61K31/215;A61K31/275;A61K31/335;A61K31/34;A61K31/35;A61K31/36;A61K31/38;A61K31/40;A61K31/415;A61K31/425;A61K31/44;C07C211/27;C07C211/29;C07C211/30;C07C217/58;C07C217/62;C07C225/16;C07C317/32;C07C323/32;C07D319/18;C07K14/705;C12N15/12;G01N33/566;G01N33/68;G01N33/84;(IPC1-7):C12N15/63;C12N15/11;C07K7/00 |
主分类号 |
A61K31/135 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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