| 发明名称 |
Methods for decreasing the expression of specifically targeted genes |
| 摘要 |
The use of oligodeoxynucleotides modified at the 3'-terminal internucleotide link as therapeutic agents by a method of hybridizing the modified oligonucleotide to a complementary sequence within a targeted mRNA and cleaving the mRNA within the RNA-DNA helix by the enzyme RNaseH to block the expression of the corresponding gene.
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| 申请公布号 |
US5962425(A) |
申请公布日期 |
1999.10.05 |
| 申请号 |
US19950460704 |
申请日期 |
1995.06.02 |
| 申请人 |
UNIVERSITY OF IOWA RESEARCH FOUNDATION |
发明人 |
WALDER, JOSEPH A.;WALDER, ROXANNE Y.;EDER, PAUL S.;DAGLE, JOHN M. |
| 分类号 |
C12N15/09;A61K48/00;C07H19/00;C07H21/00;C12N15/113;C12Q1/68;(IPC1-7):A61K48/00 |
主分类号 |
C12N15/09 |
| 代理机构 |
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代理人 |
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| 主权项 |
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| 地址 |
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