Methods for preparing novel dipeptide compounds or pharmaceutically acceptable salts thereof

摘要

The present invention provides a novel dipeptide compound or pharmaceutically acceptable salt thereof which exhibits an excellent HIV protease inhibitory activity and an excellent bioavailability from digestive tracts, and an anti-AIDS agent comprising said dipeptide compound as an effective ingredient. (wherein R1 represents 5-membered or 6-membered monocyclic hydrocarbon group or heterocyclic group wherein more than one carbon atom of said monocyclic hydrocarbon group is substituted with hetero atom. X represents methylene group (-CH2-), chloromethylene group(-CH(Cl)-), oxygen atom sulfur atom or sulfonyl group (-SO2-). R21 and R22 each represents hydrogen atom or aliphatic hydrocarbon group having 1-6 carbons. R3 represents aliphatic hydrocarbon group or monovalent group derived from aromatic monocyclic hydrocarbon having 1-6 carbons.