发明名称 |
DNA encoding p107 tumor suppressor and related polypeptides |
摘要 |
A cDNA encodes p107; a cell contains recombinant p107-encoding DNA; and substantially all of the cells of a nonhuman mammal contain recombinant p107-encoding DNA. Also, a method for diagnosing a condition of tumorigenicity in a subject, includes the steps of obtaining a tissue sample from the subject and detecting the presence of non wild-type p107-encoding gene in the sample, or detecting the absence of wild-type p107-encoding gene in the sample; or extracting DNA from the sample and detecting the presence of non wild-type p107-encoding gene or the absence of wild-type p107-encoding gene in the DNA. Also, a nucleic acid probe is complementary to a portion of a human mutant p107 gene.
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申请公布号 |
US5962315(A) |
申请公布日期 |
1999.10.05 |
申请号 |
US19930152721 |
申请日期 |
1993.11.15 |
申请人 |
DANA-FARBER CANCER INSTITUTE |
发明人 |
LIVINGSTON, DAVID M.;EWEN, MARK E. |
分类号 |
C07K14/47;C12N1/21;C12N15/12;C12Q1/68;(IPC1-7):C12N5/10;C12N15/63 |
主分类号 |
C07K14/47 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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