Benzodiazepin derivatives useful as CCK-receptor antagonists
摘要
A benzodiazepine derivative of formula (I), or a pharmaceutically acceptable salt thereof, wherein (a) R1 is -CH2CHOH(CH2)aR4 or a ketone group -CH2CO(CH2)aR5 in which a is 0 or 1 and R4 and R5 are selected from alkyl and cycloalkyl groups and saturated heterocyclic groups optionally substituted at a hetero-atom; (b) R2 and R3 are independently selected from aromatic carbocyclic and heterocylic residues; and (c) W and X are selected independently from halogen and hydrogen atoms and alkyl and alkoxy groups. These compounds are gastrin and/or CCK-B receptor antagonists.
申请公布号
US5962451(A)
申请公布日期
1999.10.05
申请号
US19970867422
申请日期
1997.06.06
申请人
FERRING BV;YAMANOUCHI PHARMACEUTICAL CO. LTD.
发明人
RYDER, HAMISH;SEMPLE, GRAEME;KENDRICK, DAVID ALAN;SZELKE, MICHAEL;SATOH, MASATO;OHTA, MITSUAKI;MIYATA, KEIJI;NISHIDA, AKITO