PAIP, A NOVEL HUMAN PROTEIN WHICH BRIDGES THE 3' AND 5' END OF MRNA, AND USE THEREOF AS A TARGET FOR TRANSLATIONAL MODULATION TO TREAT HUMAN DISEASE

摘要

The present invention relates to the process of protein synthesis in eukaryotic cells. More particularly, the present invention relates to translation and more specifically to the initiation of translation in such cells. More specifically, the present invention relates to proteins involved in the initiation of translation in animal cells, to the modulation of translation thereby and to the coupling of the 3' and 5' ends mRNA by the proteins of the present invention. The present invention also relates to isolated nucleic acid molecules encoding a human protein, a binding Protein-Interacting Protein (PAIP), as well as vectors, host cells harboring same. In addition, the present invention relates to screening assays for identifying modulators of PAIP activity.