METHOD FOR THE PREPARATION OF TYLMYCOSIN

摘要

The method includes cultivation of strain Streptomyceshydroscopicus ZM - 8,. registered under No. 2413 in NBIMCC,produced by induced mutagenesis withN-methyl-N-nitro-N-nitrosoguanidine on museum culture Streptomyceshygroscopicus NRRL 3017 and subsequent degree selection. Theprocess runs under aerobic conditions in nutrients containingsources of nitrogen, carbon and mineral salts. As intermediateproduct 20-dihydro-20-hydroxy desmycosin is synthetized from thestrain which is chemically transformed by binding tocis-3,3-dimethylpiperidine to tylmycosin which separated andpurified.1 claim