PHARMACEUTICAL FORMULATION COMPRISING A 2-[[(2-PYRIDINYL)METHYL]SULFINYL]BENZIMIDAZOLE HAVING ANTI-ULCER ACTIVITY AND A PROCESS FOR THE PREPARATION OF SUCH FORMULATION

摘要

Oral pharmaceutical formulation comprising granules having an inert core coated with a layer, comprising a 2-¢¢(2-pyridinyl)methyl!sulfinyl!benzimidazole having anti-ulcer activity, a disintegrant and a surfactant in a matrix of a melt coating substance essentially consisting of one or more esters of glycerol and fatty acids, a separating layer and an enteric coating layer, and a process for the preparation of such formulation using a melt coating technique for the preparation of the benzimidazole containing layer.