发明名称 |
PERIPHERAL-TYPE BENZODIAZEPINE RECEPTOR: A TOOL FOR DETECTION, DIAGNOSIS, PROGNOSIS, AND TREATMENT OF CANCER |
摘要 |
The expression and subcellular localization of peripheral-type benzodiazepine receptors (PBR) is shown in this application to correlate with the metastatic potential of cells, and increased cell proliferation. Inhibition of PBR expression, function or stability results in a decrease in cell proliferation. Compositions and methods for regulating and/or monitoring PBR and its expression are useful for the detection, diagnosis, prognosis and treatment of solid tumors, in particular, breast cancer.
|
申请公布号 |
CA2325445(A1) |
申请公布日期 |
1999.09.30 |
申请号 |
CA19992325445 |
申请日期 |
1999.03.25 |
申请人 |
GEORGETOWN UNIVERSITY MEDICAL CENTER |
发明人 |
CULTY, MARTINE;PAPADOPOULOS, VASSILIOS |
分类号 |
A61K31/711;A61K39/395;A61K45/00;A61K48/00;A61P35/00;A61P43/00;C07K14/705;C07K16/28;C12N5/10;C12N15/09;C12Q1/02;C12Q1/48;C12Q1/68;G01N33/574;G01N33/68;(IPC1-7):C12N15/12;C12P21/02;C12N5/08;A61K38/17;C12N1/21;A61K31/55;G01N33/566;C12N15/63;A61K31/70 |
主分类号 |
A61K31/711 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|