发明名称 |
HIGH DENSITY PROTEIN ARRAYS FOR SCREENING OF PROTEIN ACTIVITY |
摘要 |
The present invention relates to protein chips useful for the large-scale study of protein function where the chip contains densely packed reaction wells. The invention also relates to methods of using protein chips to assay simultaneously the presence, amount, and/or function of proteins present in a protein sample or on one protein chip, or to assay the presence, relative specificity, and binding affinity of each probe in a mixture of probes for each of the proteins on the chip. The invention also relates to methods of using the protein chips for high density and small volume chemical reactions . Also, the invention relates to polymers useful as protein chip substrates an d methods of making protein chips. The invention further relates to compounds useful for the derivatization of protein chip substrates.
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申请公布号 |
CA2408291(A1) |
申请公布日期 |
2001.11.08 |
申请号 |
CA20012408291 |
申请日期 |
2001.05.04 |
申请人 |
YALE UNIVERSITY |
发明人 |
REED, MARK;KLEMIC, JAMES FRANK;ZHU, HENG;SNYDER, MICHAEL |
分类号 |
G01N27/62;B01J19/00;B01L3/00;B81C1/00;C07K17/08;C07K17/12;C12N11/08;C12N11/14;C40B40/06;C40B40/10;C40B60/14;G01N21/78;G01N33/50;G01N33/53;G01N33/543;G01N33/566;G01N33/577;G01N37/00;(IPC1-7):C12Q1/68 |
主分类号 |
G01N27/62 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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