发明名称 |
SLOW RELEASE MICROCAPSULES |
摘要 |
The inventive method for producing microcapsules is characterised in that a) in one step, liquid drops of an aqueous solution (1) containing at least one water-soluble polyanion are added to an aqueous solution (2) containing the following: 0.1 to 5 wt. % calcium cations; and 0.1 to 5 wt. % hydrolyzed chitosan with a number average molecular weight of between 2,200 and 40,000 g/mol., obtained by partial hydrolysis of a chitosan with a number average molecular weight of more than 50,000 g/mol. in an aqueous solution containing 0.1 to 4 N HCl at a temperature of between 50 and 95 DEG C for 0.5 to 8 hours, the weight ratio of the solution containing HCl to usual commercial chitosan being between 1 and 50 and the product of normality of the HCl solution and the duration of hydrolysis in hours being between 0.1 and 7; and in that b) once the addition of solution 1 is complete, the resulting microcapsules remain in solution 2 for a duration of 15 to 360 minutes, preferably 60 to 180 minutes. |
申请公布号 |
WO9948479(A1) |
申请公布日期 |
1999.09.30 |
申请号 |
WO1999EP01625 |
申请日期 |
1999.03.12 |
申请人 |
AVENTIS RESEARCH & TECHNOLOGIES GMBH & CO. KG;BAYER, UWE;HAHN, BERND;MAJERES, ANNA |
发明人 |
BAYER, UWE;HAHN, BERND;MAJERES, ANNA |
分类号 |
A61K8/11;A61K8/73;A61K9/16;A61K9/50;A61K47/36;A61Q13/00;B01J13/02;B01J13/10 |
主分类号 |
A61K8/11 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|