发明名称 |
DRM, A SECRETED PROTEIN WITH CELL GROWTH INHIBITING ACTIVITY, AND RELATED METHODS AND COMPOSITIONS |
摘要 |
The present invention provides an isolated nucleic acid encoding DRM protein, an isolated DRM polypeptide, and a fusion polypeptide comprising a DRM protein and a green fluorescent protein. The present invention also provides a method of arresting the growth of a cell, comprising administering to the cell an effective amount of DRM protein or an active fragment thereof; a method of inhibiting tumor cell growth, comprising administering to a tumor cell an effective amount of DRM protein or an active fragment thereof; and a method of treating a hyperproliferative cell disorder in a subject diagnosed with a hyperproliferative cell disorder, comprising administering to the subject an effective amount of DRM protein or an active fragment thereof, in a pharmaceutically acceptable carrier. In addition, the present invention provides a method of arresting growth of a cell, comprising administering to the cell an effective amount of a nucleic acid encoding a DRM protein or an active fragment thereof; a method of inhibiting tumor cell growth, comprising administering to a tumor cell an effective amount of a nucleic acid encoding a DRM protein or an active fragment thereof; and a method of treating a hyperproliferative cell disorder in a subject diagnosed with a hyperproliferative cell disorder, comprising administering to a cell of the subject, in a pharmaceutically acceptable carrier, an effective amount of a nucleic acid encoding a DRM protein or an active fragment thereof, under conditions whereby the nucleic acid is expressed in the subject's cell.
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申请公布号 |
WO9949041(A1) |
申请公布日期 |
1999.09.30 |
申请号 |
WO1999US06675 |
申请日期 |
1999.03.26 |
申请人 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES |
发明人 |
BLAIR, DONALD, G.;CLAUSEN, PETER, A.;TOPOL, LILIA, Z.;MARX, MARIA;CALOTHY, GEORGES |
分类号 |
A61K38/00;A61K48/00;C07K14/435;C07K14/475;C12N15/12;(IPC1-7):C12N15/12;C12N15/62;C07K19/00;C12Q1/68;C07K16/18;G01N33/50;G01N33/53;A61K38/18 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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