| 摘要 |
<p>Oxirane derivatives which have a high purity and a high molecular weight and are useful as a material for medicinal applications, mainly drug delivery systems; and a process for producing the oxirane derivatives. The oxirane derivatives are represented by the general formula RO(C2H4O)nH (wherein R is a C1-7 hydrocarbon group and n is 20 to 900), give (A) a gel permeation chromatogram which satisfies the relationship PareaM/Parea ≥ 0.85 [wherein Parea is the total peak area above the base line (PbaseL); and PareaM is the area of that part of the peak which ranges from the point at which the height of the elution curve extending from the elution initiation point toward the peak top (Ptop) is 1/5 the peak height (PtopH) to the point at which the height of the elution curve extending from the Ptop toward the elution termination point is 1/5 the PtopH], and give (B) a thin-layer chromatogram showing that the main spot ranging in Rf value from 0.2 to 0.8 has a purity of 98 % or higher. The process comprises reacting ROH with oxirane while regulating the water content in the reaction system to 5 ppm or lower.</p> |
