SERINE PROTEASE VARIANTS HAVING AMINO ACID SUBSTITUTIONS

摘要

The present invention relates to variants of serine proteases having decreas ed immunogenicity relative to their corresponding wild-type proteases. More particularly, the present invention relates to variants having a modified amino acid sequence of a wild-type amino acid sequence, wherein the modified amino acid sequence comprises a substitution of one or more specifically identified positions corresponding to subtilisin BPN'. The invention further relates to mutant genes encoding such variants and cleaning and personal car e compositions comprising such variants.