ANTISENSE OLIGONUCLEOTIDE MODULATION OF HUMAN HER-2 EXPRESSION
摘要
Compounds, compositions and methods are provided for inhibiting the expression of human HER-2 (also known as c-neu, ErbB-2 and HER-2/neu). The compositions comprise antisense oligonucleotides targeted to nucleic acids encoding HER-2. Methods of using these oligonucleotides for inhibition of HER-2 expression and for treatment of diseases such as cancers associated with overexpression of HER-2 are provided. Methods of inhibiting other growth factor receptors using antisense oligonucleotides targeted to nucleic acids encoding HER-2 are also provided.
申请公布号
WO9948906(A1)
申请公布日期
1999.09.30
申请号
WO1999US06492
申请日期
1999.03.25
申请人
ISIS PHARMACEUTICALS, INC.;THE PENN STATE RESEARCH FOUNDATION;BENNETT, C., FRANK;LIPTON, ALLAN;WITTERS, LOIS, M.
发明人
BENNETT, C., FRANK;LIPTON, ALLAN;WITTERS, LOIS, M.