HYPOXIA-INDUCIBLE HUMAN GENES, PROTEINS, AND USES THEREOF

摘要

The polynucleotide and polypeptide sequences of two novel hypoxia-inducible human genes, HIG1 and HIG2, are described. In addition, a number of known genes have now been established as being hypoxia-inducible. These genes include annexin V, lipocortin 2, hnRNP A1, Ku autoantigen, phosphoribosylpyrophosphate synthetase, acetoacetylCoA thiolase, ribosomal L7, fibroblast growth factor-3, EPH receptor ligand, plasminogen activator inhibitor-1, macrophage migration inhibitory factor, fibronectin receptor, lysyl hydroxylase-2, endothelin-2, B-cell translocation gene-1, reducing agent and tunicamycin-responsive protein, CDC-like kinase-1, quiescin, growth arrest DNA damage-inducible protein 45, DEC1, low density lipoprotein receptor related protein, hamster hairy gene homologue, adipophilin, cyclooxygenase-1, fructose bisphosphatase, creatine transporter, fatty acid binding protein, lactate dehydrogenase, Bcl-2-interacting killer, Nip3L/Nix, and Pim-1. Polynucleotide and polypeptide arrays comprising the hypoxia-inducible gene sequences, proteins, or antibodies which specifically bind the proteins are disclosed. Methods for using the hypoxia-inducible gene sequences and proteins, and arrays thereof, to diagnose and treat hypoxia-related conditions such as cancer and ischemia are also provided.