发明名称 Derivatives of phenoxy acetic acid and of phenoxymethyl tetrazole having antitumor activity.
摘要 The present invention relates to the use derivatives of phenoxy acetic acid and of phenoxymethyl tetrazole of formula (I) <CHEM> wherein A, B, R1, R2, R4, p, n and m have the above-stated meanings, their pharmaceutically acceptable acids or basis to produce pharmaceutical agents for the treatment of diseases where MDM2 antagonistic activity is involved, processes for their production and pharmaceutical agents which contain these compounds having MDM2antagonistic activity.
申请公布号 ZA9902407(B) 申请公布日期 1999.09.30
申请号 ZA19990002407 申请日期 1999.03.29
申请人 F. HOFFMANN-LA ROCHE AG. 发明人 ROBERTO DI DOMENICO;BRIGITTE KALUZA;RALF SCHUMACHER;SILKE HANSEN;ERNESTO MENTA
分类号 A61K31/00;A61K31/19;A61K31/192;A61K31/24;A61K31/41;A61P35/00;A61P43/00;C07C45/62;C07C45/74;C07C49/83;C07C49/835;C07C59/90;C07C69/712;C07C235/76;C07D257/04 主分类号 A61K31/00
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