发明名称 Pharmaceutical agents containing methotrexate derivative
摘要 PCT No. PCT/JP96/00780 Sec. 371 Date Sep. 25, 1997 Sec. 102(e) Date Sep. 25, 1997 PCT Filed Mar. 26, 1996 PCT Pub. No. WO96/30019 PCT Pub. Date Oct. 3, 1996Compounds represented by the general formula: (where R1 is one member selected from the group consisting of CH2, CH2CH2, CH2O, CH2S and CH2SO; R2 is a hydrogen atom or a lower alkyl group having 1-4 carbon atoms or a benzyl group; R3 is a group represented by the general formula COOR4, the general formula NHCOR5, the general formula CONR6R7, PO3H2 or SO3H; and n is an integer of 1-4) or salts therof are useful as therapeutic agents of autoimmune diseases such as systemic lupus erythematosus and nephritic diseases such as glomerulonephritis.
申请公布号 US5958928(A) 申请公布日期 1999.09.28
申请号 US19970913967 申请日期 1997.09.25
申请人 CHUGAI SEIYAKU KABUSHIKI KAISHA 发明人 MIHARA, MASAHIKO
分类号 A61K31/519;A61K31/5415;C07D475/08;(IPC1-7):A61K31/505 主分类号 A61K31/519
代理机构 代理人
主权项
地址