发明名称 |
Tricyclic compounds useful as inhibitors of farnesyl-protein transferase |
摘要 |
Novel tricyclic compounds and pharmaceutical compositions are disclosed which are inhibitors of the enzyme, farnesyl protein transferase. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering the novel tricyclic compound to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammals such as a human.
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申请公布号 |
US5958940(A) |
申请公布日期 |
1999.09.28 |
申请号 |
US19970927728 |
申请日期 |
1997.09.11 |
申请人 |
SCHERING CORPORATION |
发明人 |
RANE, DINANATH F.;COOPER, ALAN B.;MALLAMS, ALAN K.;DOLL, RONALD J.;NJOROGE, F. GEORGE;TAVERAS, ARTHUR G. |
分类号 |
C07D401/14;(IPC1-7):A61K31/44 |
主分类号 |
C07D401/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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