发明名称 |
DNA encoding the T cell surface protein T4 and use of fragments of T4 in the treatment of AIDS |
摘要 |
A single-stranded nucleic acid molecule which encodes an amino acid sequence comprising at least a portion of a T4 glycoprotein is provided. Additionally, amino acid sequences which comprise at least a portion of a T4 glycoprotein and are useful as a prophylaxis for treating a subject with acquired immune deficiency syndrome are provided. These amino acid sequences, which are capable of specifically forming a complex with a human immunodeficiency virus envelope glycoprotein and which are soluble in an aqueous solution may be administered to a subject infected with a human immunodeficiency virus so as to block the human immunodeficiency virus from binding to T4+ cells. Monoclonal antibodies directed to the water-soluble amino acid sequences of the present invention may be used as vaccines for immunizing a subject against acquired immune deficiency syndrome.
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申请公布号 |
US5958678(A) |
申请公布日期 |
1999.09.28 |
申请号 |
US19940354452 |
申请日期 |
1994.12.12 |
申请人 |
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK |
发明人 |
MADDON, PAUL J.;LITTMAN, DAN R.;CHESS, LEONARD;AXEL, RICHARD;WEISS, ROBIN;MCDOUGAL, J. STEVEN |
分类号 |
A61K38/00;C07K14/725;C07K14/73;C12N15/12;(IPC1-7):C12Q1/68;C07K1/00;A61K45/05;A61K39/38 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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