发明名称 |
Phosphonic acid-based cationic lipids |
摘要 |
The present invention provides novel phosphonic acid-based cationic lipids of the general structure: or a salt, or solvate, or enantiomers thereof wherein; (a) R1 is a lipophilic moiety; (b) R2 is a positively charged moiety; (c) R3 is a lipophilic moiety of 1 to about 24 carbon atoms, a positively charged moiety, or a negatively charged moiety; (d) n is an integer from 0 to 8; (e) X- is an anion or polyanion; (f) Y is N or O, and (g) m is an integer from 0 to a number equivalent to the positive charge(s) present on the lipid. The present invention further provides compositions of these lipids with polyanionic macromolecules, methods for interfering with protein expression in a cell utilizing these compositions and a kit for preparing the same.
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申请公布号 |
US5958901(A) |
申请公布日期 |
1999.09.28 |
申请号 |
US19960665055 |
申请日期 |
1996.06.05 |
申请人 |
GENTA INCORPORATED |
发明人 |
DWYER, BRIAN PATRICK;LEHEDEV, ALEXANDRE V.;BROWN, BOB DALE;SCHWARTZ, DAVID AARON |
分类号 |
C12N15/09;A61K9/127;A61K31/66;A61K31/70;A61K45/06;A61K47/24;A61K47/28;A61K47/48;A61K48/00;C07F9/40;C07J9/00;C07J41/00;C07J43/00;C07J51/00;(IPC1-7):A61K31/665 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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