Cytoplasmic modulators of integrin regulation/signaling

摘要

The present invention provides purified and isolated polynucleotides encoding IRP (integrin regulatory protein) polypeptides which regulate beta 2 and beta 7 integrins and which are contemplated to participate in integrin signaling and/or recycling pathways. Also provided are methods for identifying modulators of IRP activities and methods for identifying other proteins which interact with IRP polypeptides in signaling pathways. Modulators of IRP interactions are contemplated to be useful, for example, in monitoring and treating inflammatory processes involving leukocytes.