发明名称 |
Heat shock protein peptides and methods for modulating autoimmune central nervous system disease |
摘要 |
The invention provides for peptides and methods of using peptides to block or inhibit a pathogenic autoimmune response to central nervous system components. One class of peptides are antigens derived from mycobacterial heat shock proteins and may immunologically cross-react with or are homologous to myelin components. The peptides can also be derived from myelin components such as 2',3' cyclic nucleotide phosphodiesterase and immunologically cross-react with and/or are homologous to mycobacterial heat shock proteins. A method of the invention involves administering a pharmaceutical composition including at least one peptide to an animal in an amount effective to block or inhibit a pathogenic autoimmune response to central nervous system components. The peptides are useful for the prevention, and treatment of autoimmune inflammatory central nervous system disease.
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申请公布号 |
US5958416(A) |
申请公布日期 |
1999.09.28 |
申请号 |
US19950447154 |
申请日期 |
1995.05.23 |
申请人 |
REGENTS OF THE UNIVERSITY OF MINNESOTA;MCGILL UNIVERSITY |
发明人 |
BIRNBAUM, GARY;KOTILINEK, LINDA A.;BRAUN, PETER ERICH |
分类号 |
A61K38/00;A61P37/00;A61P37/02;C07K14/35;C07K14/47;C12N9/16;(IPC1-7):A61K39/02 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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