发明名称 |
Nitric oxide donor compounds and pharmaceutical compositions for pulmonary hypertension and other indications |
摘要 |
The invention is directed to nitric oxide (NO) donor compounds and to pharmaceutical compositions containing such nitric oxide (NO) donor compounds, for delivering NO to the apical surface of a mucosa, where the nitric oxide is released for passage across the epithelial monolayer of the mucous membrane. The NO donor compounds include polyalkyleneamine NO donors as well as tertiary and quaternary amino aliphatic NO donor compounds. The compounds and compositions of the invention are useful in any situation in which it is desirable to deliver NO across a mucosal surface. For example, the compounds and compositions of the invention are particularly useful in treating pulmonary hypertension, male impotence, and several other specific conditions.
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申请公布号 |
US5958427(A) |
申请公布日期 |
1999.09.28 |
申请号 |
US19960746431 |
申请日期 |
1996.11.08 |
申请人 |
SALZMAN, ANDREW L.;SMITH, DANIEL J.;SZABO, CSABA;BRILLI, RICHARD J.;KRAFTE-JACOBS, BRIAN |
发明人 |
SALZMAN, ANDREW L.;SMITH, DANIEL J.;SZABO, CSABA;BRILLI, RICHARD J.;KRAFTE-JACOBS, BRIAN;JACOBS BRIAN |
分类号 |
A61K8/00;A61K8/41;A61K31/13;A61K31/131;A61K31/15;A61P1/02;A61P9/00;A61P11/00;A61P15/00;A61P15/10;A61P43/00;A61Q11/00;C07C243/42;C07C291/04;C08F8/30;C08G73/02;(IPC1-7):A61K9/00 |
主分类号 |
A61K8/00 |
代理机构 |
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地址 |
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