Human interleukin-4 antagonist/agonist screens

摘要

Stably-transformed human cell lines containing a reporter gene operatively linked to an IL-4-responsive element are provided. In some embodiments a human Fc epsilon RII IL-4-responsive element is used. In other embodiments a human germline epsilon transcript promoter is used as the responsive element. Also provided are methods for using such transformed cell lines to screen for agonists and/or antagonists of human interleukin-4.