发明名称 |
Compositions and methods for mediating cell cycle progression |
摘要 |
Inhibitors of the p27 cyclin dependent kinase inhibitor protein or sequences encoding the protein modulate vertebrate cell cycle progression and increase the proportion of dividing cells to non-dividing cells in a population of treated cells. As the proportion of dividing cells increases, the cell population, e.g., hematopoietic progenitor (stem) cells, is more efficiently used for gene therapy applications.
|
申请公布号 |
US5958769(A) |
申请公布日期 |
1999.09.28 |
申请号 |
US19960588595 |
申请日期 |
1996.01.18 |
申请人 |
FRED HUTCHINSON CANCER RESEARCH CENTER |
发明人 |
ROBERTS, JAMES M.;COATS, STEVEN R.;FERO, MATTHEW L. |
分类号 |
A61K38/00;A61K48/00;C07K14/47;C12N15/82;(IPC1-7):C12N15/79;C12N5/10;A01N43/04;C07H21/04 |
主分类号 |
A61K38/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|